Human Blood Albumen significance

Blood products are widely used to replace blood or particular components of the blood that have been lost by accident or illness in the human body. These products can be extracted from the human blood and used for the medication purpose for many ailing and life fighting patents and also for transfusion purpose. All blood products are made from blood collected from volunteer blood donors that donate their blood and all other such Human Blood Products for the help of researches and medicine development purposes.

Human Serum Albumin is also one of such rare element that has proven to be very useful in development of various medicines and therapies. It is also one of the major constituent of human blood which when extracted can be very useful for the development of various medicines and vaccines.

Albumins are commonly found in blood plasma, and are unique from other blood proteins as they are not glycosylated in nature.  is the most abundant protein in human blood plasma which is produced in the liver of human body. Albumin constitutes about half of the blood serum protein and is responsible for the transport of all hormones, fatty acids, and other compounds, buffers pH, and for maintaining osmotic pressure, among other major functions of the human body.

Albumins are soluble and monomeric in nature. These when extracted are preserved in the powdered form for the future use, for the development of medicines and various therapies. Human Serum Albumin is available for medical use, usually at concentrations of 5-25% as the albumen levels can affect the life of drugs to some extent. Also, an excess and lack of albumin can have very bad effect on the human body.

Human Serum Albumin is very essential for maintaining the osmotic pressure needed for proper distribution of body fluids between all the body tissues and parts of the body. This substance acts as a plasma carrier by nonspecifically binding several hydrophobic steroid hormones and as a transport protein for hemin and fatty acids throughout the human body. However excess serum albumin in the body can be harmful though. Human Serum Albumin is often used to replace lost fluid and help restore blood volume in trauma, burns and surgery patients. This is preserved for all such future medical and research uses.

All these Human Blood Products when extracted from the human body cause no harm to the donors, and can be easily regenerated in the body within small period of time. Though after the donation the donor may face little of dizziness or discomfort, which is though very minor at times. All these Human Blood Products are very useful in the preparation of medications or drugs for some of the rare and chronic diseases throughout the world. Many therapies and vaccines are made using these products from the human blood. These substances works wonders when present in the body by providing the accurate flow of blood and plasma in the human body and when taken out works as a life saving substance for many dangerous and chronic diseases.

While such transmissions and extractions with zero risk of transmitting infectious disease may not be possible, but with the development of latest technologies least possible risk are being recorded as all the transmissions are tested for such issues and least possible issues or side effects are attained. As Human Blood Products are likely always to carry an inherent risk of infectious agents zero risk may be unattainable. The role of new donor locations is to drive that risk to the lowest level reasonably achievable without unduly decreasing the availability of this life saving resource and its medical quality.

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Globulins of the human blood

In the human biochemistry study, the blood components are widely divided. Human plasma being one of the important constituent is majorly responsible for the accurate flow of blood in the human body. Human plasma is made up of water and proteins and occupies almost 55% of total blood volume in the human body. However this substance is a regenerating substance in the body which can be easily formed again by it, so can be donated for medication or research purposes without causing any deficiency to the body.

In the human plasma there are 3 types of serum proteins present albumin, fibrinogen and Globulin. When the fibrinogen is separated from the plasma it becomes the serum part. Fibrinogen is the clotting part of the blood. Albumin is also a globular protein, but not a globulin. All other serum globular proteins except the albumin are globulins. Some globulins are produced in the liver, while others are produced by the immune system of the human body.

The serum globulins are categorized into 4 types based on its properties. Protein electrophoresis is the method which is used to categorize these serum globulins into the following four categories:

·         Alpha 1 globulins

·         Alpha 2 globulins

·         Beta globulins

·         Gamma globulins

Alpha globulins are a group of the globular proteins that are very volatile in an electrically charged solution or the alkaline solutions. These alpha globulins withhold several blood enzymes in it. There are various types of alpha globulins which are further divided into Alpha 1 and Alpha 2.

Beta globulins are also same like the Alpha globulins but are less volatile when compared to them. This is a globulin in blood plasma that carries iron and are transport proteins, serving as a substrates upon which other substances are formed, and perform other diverse functions in the human body.

Gamma globulins are the type of globulins that are identified by their position after the process electrophoresis is done for the extraction of serum protein. These are the antibodies which are very crucial in the development of various medications and therapeutic use. Being the heaviest, they are the slowest to segregate in Electrophoresis. Since they are immunologically active, they are also called as Immunoglobulin. These are very important part of human blood as their excess and deficiency both are not good for health and can cause a disease called "gammopathy". An excess of it is called as “hypergammaglobulinemia” whereas deficiency is called as “hypogammaglobulinemia”.

Injections are given to the patients to boost immunity in patients who are unable to produce the required gamma globulins quantity naturally because of an immune deficiency. Such injections are less common in modern medical practice than they were previously, as they have been replaced by the use of hepatitis A vaccine. However, being a substance taken from blood, gamma globulin injections, along with blood transfusions and intravenous drug use, could pass along Hepatitis C to its recipient, which is the major cause of its replacement in the medical use. Apart from gamma globulins, there are medications available foe alpha and bets too in the world which can be taken.

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