Serum globulin
electrophoresis is a laboratory test that is carried out to examine a specific
type of protein in the human blood called as the globulins. The globulins are
a family of globular proteins that are mostly produced in the liver and
also some of them are formed by the immune system of the human body. These
proteins have a high water solubility level and come in different sizes. These Serum Globulins help the
humans in the proper functioning of the various vital body functions and also
to safeguard the body against various diseases and infections. These substances
are the important constituents of human blood.
The serum globulin
electrophoresis method is carried out by collecting blood samples from
different Serum Donor
Locations and performing needed tests and examinations
on the donor samples. When the blood samples are collected the blood is kept
for clotting so that the liquid portion of the blood called serum is obtained.
Once the serum is collected this laboratory
technique called Serum
globulin electrophoresis is carried out. In this
method the collected serum is placed on a specially
treated paper containing agarose gel on it that is usually used to separate macromolecules
and their fragments. Now this paper along with the serum placed on it is
exposed to an electric current. The proteins present in the serum move on
the paper and form bands indicating the amount of each protein fraction due to
the electric charge. Here all the serum proteins are separated and five major
fractions are formed. They are serum albumin, alpha-1 globulins, alpha-2 globulins, beta globulins, and gamma globulins. They also include
various types of antibodies such as immune globulins (Ig) M, G, and A.
This test is performed to look at various globulin proteins
present in the human blood. Identifying the types of globulins by Serum globulin
electrophoresis can help diagnose certain disorders and acute
medical conditions. The separated serum proteins can be further used to
synthesize various vaccines, therapies and medicines that can help people
suffering various chronic diseases.
However, the reports obtained from this test will also identify the amount
of globulins proteins present in the individual human body, as an excess and
scarce level of proteins can lead to many medical disorders in the individual.
Some of the conditions that are generally traced with increased gamma globulin
protein levels are chronic inflammatory disease like rheumatoid arthritis and systemic lupus erythematosus,
Hyperimmunization, Multiple myeloma and many other acute infections. In such conditions the
separated proteins can be utilized either by transfusions or medical substitutes
formed by these substances.
Here are few concerns associated with this Serum globulin
electrophoresis method. The donors must not intake any food 4 hours prior to
the test and must avoid drug intake if any as these products may affect the
test and produce inadequate reports. Also, the donors that are giving their
samples at Serum Donor
Locations may experience little pain or a stinging sensation as the blood is usually collected using a syringe. The
pain experience may differ from individual to individual. The medical staff
present at the Serum Donor
Locations will however take care of this concern as
minute fault can leave the donor in many critical conditions like excessive
bleeding, Infections and also fainting at times. The medical staff must be
professional in both collecting the blood samples as well carrying out the
entire process as little misconceptions can leave faulty reports.
No comments:
Post a Comment